Study Purpose/Description
A range of low-calorie (or “non-nutritive”) sweeteners have been used as “healthy” substitutes for sugar in foods and beverages. However, large population studies suggest that regular intake of these sweeteners can increase the risk of developing type 2 diabetes. Whether some sweeteners are better than others remains unclear.
We will supplement study participants with one of five low-calorie sweeteners (acesulfame-K, aspartame, stevia, sucralose, saccharin) or placebo, provided in capsules over 4 weeks, and assess the impact of these sweeteners on blood glucose control and the absorption of glucose from the intestine, and whether they modify the bacteria present in the intestines.
What’s involved?
The study requires 4 study visits, each lasting 4-5 hours, at the Adelaide Health and Medical Sciences (AHMS) building. Two of these visits will involve collection of blood and breath samples following a glucose drink. The other two involve infusion of glucose into the small intestine through a soft tube inserted through the nose, with collection of blood and urine samples. We will also be collecting information about food intake using diet diaries, and will collect a stool sample at the beginning and end of the study.
Upon completion of our study (Approx. 5 week duration from beginning to end with four half day study visits), participants will receive an honorarium of up to $350 via EFT transfer.
Want to learn more?
If you are interested and think you might be eligible, you can:
- Complete a screening survey – All completed responses prompt contact from the research team.
- Email the researchers at diabetes@adelaide.edu.au
- or call 08 8313 6676
