The ATHENA study is investigating methods of lowering blood pressure to reduce the risk of cognitive decline and dementia in persons aged 50-70 years.

Study description/purpose

Dementia, and the cognitive decline that precedes it, are feared and increasingly common disorders in our populations.  In Australia, an estimated 250 people are newly diagnosed with dementia each day. Around the world, there is a new case every three seconds around the world, with numbers predicted to rise to 152 million by 2050.

Dementia represents a diagnostic point in a long disease process that begins symptom-free with pathology occurring 20 to 30 years prior to diagnosis.  As no medications are currently available to treat dementia, the best option is prevention through early intervention of those at increased risk of the condition.  

Over 30 potential modifiable dementia risk factors have been proposed, but recent World Health Organisation guidelines for dementia risk reduction made strong recommendations for blood pressure (BP) lowering.

The study aims to determine the feasibility of an online and telehealth clinical trial of more intensive BP-lowering provided by a ‘Triple Pill’ strategy as an adjunct to standard care, compared to standard care, on the attenuation of cognitive decline in midlife participants who are at a greater than average risk of developing dementia in later life.

What’s Involved?

Randomised participants will receive study medication for 4 weeks, and all visits will be conducted remotely.

Disease or condition

Cognitive Dysfunction, Cognitive Impairment, Cognitive Decline, Hypertension

Recruitment criteria

The study is open to people who:

  • Have mild memory problems
  • Are aged between 50-70 years old
  • Lives in New South Wales
  • Have elevated blood pressure over 120/80


Reimbursement for any travel/parking costs incurred when travelling for pathology tests.

Study sponsor / funder

Research team contacts

(02) 8052 4652

Register your interest

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