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MeTeOR2 Study

Sydney University researchers want to understand which treatments for people with pain and/or functional limitations post partial-meniscectomy are more effective for pain and self-reported functioning.

  • Knee Pain

Study Purpose/Description

MeTeOR2 is a randomised controlled trial comparing meniscal allograft transplant surgery to personalised knee therapy in people with pain and/or functional limitations post partial-meniscectomy.

The study aims to identify if one treatment is superior to another for pain and self-report functioning.

What’s Involved?

Taking part in the MeTeOR2 study involves participants being randomly assigned into one of two groups.

  • The first group will receive a meniscal allograft transplant surgery. This surgery involves the implantation of a meniscus which has been procured from a deceased person into a meniscal deficient knee.
  • The second group will receive personalised knee therapy. This will involve an assessment of your knee and functioning, and the prescription of a treatment plan tailored to your needs based on this assessment.

Participants in both groups will be asked to complete a series of questionnaires at baseline and 3-, 6-, 12-, 18-, and 24-months following randomisation. The primary outcome will be collected at 24-months after randomisation.

Disease or condition

Knee Pain

Recruitment criteria

The study is open to people who:

  • Experience pain and / or functional limitation from the knee, severe enough to warrant potential meniscal allograft transplant, and
  • Have had a previous meniscectomy ≥ six months ago.

Additional exclusion criteria may apply after evaluation by the assessing clinician. This will include:

  • Symptomatic ligament instability, not previously corrected, as determined by the assessing clinician.
  • Coronal limb alignment which requires surgical correction, as determined by the assessing clinician.
  • Age < 16, or if ≥ 16, open growth plate at the proximal tibia as judged by the clinical team on imaging as part of standard care.
  • Full thickness cartilage loss (exposed bone) > 1 cm2, on routine clinical MRI, prior to surgery, or any other form of clinical imaging or evaluation.
  • Inflammatory arthritis affecting the study knee as determined by the assessing clinician.
  • Unable or unwilling to engage with rehabilitation.
  • Unable to adhere to trial processes.
  • Previous randomisation in the present trial, (i.e., the other knee).

Study sponsor / funder

Research team contacts

Research Team

[email protected]

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